Effects of Echinacea Purpurae Extract on Testicular Ischemia/Reperfusion (I/R) Injury in Rat

Authors

  • Ahmad Asghari Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Alireza Jahandideh Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Gholamreza Abedi Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Pejman Mortazavi Department of Veterinary Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Sadegh Motamedi Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract:

BACKGROUND: Ischemia/reperfusion of tetsis is a male infertility condition which occurs because of oxidation demage. Echinacea purpurea extract (EPE) has antioxidant and protective effect. OBJECTIVES: So, the main purpose of this research was to determine effects of EP extract on testicular ischemia/reperfusion (I/R) injury in rat. METHODS: 50 adult Wistar rats were randomly allocated into five groups: group one as control, group two, 2 hour I/24 hours R period, group three, 1 hour I which after 1 hour of ischemia, rat was injected 25 mg/kg EPE and ischemia continued for an hour, then was followed by 24 hours R period. Groups 4 and    5 were similar to experiment 3, except rats were injected with 50 and 100 mg/kg of EPE, respectively.  Then 24 hours later, the left testis was removed for histological and antioxidant enzyme activity including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS). RESUTLS: Based on the findings, MDA concentration was significantly elevated in I/R rat (P

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Journal title

volume 13  issue 3

pages  303- 313

publication date 2019-09-01

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